Patients suffering from central neuropathic pain due to MS (Multiple Sclerosis) have been using PEA to relieve this pain, and from the 20 patients, 15 had moderate relief.

What is Multiple Sclerose (MS)?

MS is a chronic disease caused by an unknown inflammation in the nervous system leading to the breakdown of the isolating layer around the nerves (myelin). The nerves get chronically inflamed during the MS process. Basically, however, the main causes are unknown and MS is still incurable, although a number of new immunomodulating drugs have proven to be able to stop the disease for some time progressing.

Treatment of Multiple Sclerose

Pain and muscle spasms that are symptoms of MS which lower quality of life considerably. One of the safe alternatives to treat pain and muscle spasms in MS is PEA, a natural compound that is naturally present in the body, available as a dietary supplement. PEA is not only a natural painkilling but it has significant anti-inflammatory properties. Next, to it, it may promote the restoration of nerves.

Many patients with MS have documented their experiences: reduction of pain and spasms when they use PEA.

For pain relief and for inhibiting inflammation, most patients choose:

  • PEA capsules produced in the Netherlands by Russell
  • PEA tablets produced in Italy by Epitech

Pharmacologists wrote recently:

“Our results enhance our understanding of mechanisms related to the anti-inflammatory property of the PEA suggesting that this molecule may represent a crucial therapeutic intervention both diminishing the immune/inflammatory response and promoting the initiation of neurotrophic substance after spinal cord injury.

Recommendation for use of PEA

PEA-opt® is a quality mark used exclusively for products that contain optimized palmitoylethanolamide (PEA). Optimized palmitoylethanolamide is natural PEA prepared by means of a modern patent for formulation. That’s why the PEA particles have a special quality, fineness and are finely distributed, enabling this product to optimally support the intake process in the body. This contributes to its effectiveness.


(Esposito E, Paterniti I, Mazzon E, Genovese T, Di Paola R, Galuppo M, Cuzzocrea S.Effects of palmitoylethanolamide on the release of mast cell peptidases and neurotrophic factors after spinal cord injury. Brain Behav Immun. 2011 Aug;25(6):1099-112. doi: 10.1016/j.bbi.2011.02.006. Epub 2011 Feb 25.)