Italian pharmacologists specialized in inflammation research explored the activity of PEA in a model for a specific eye disorder: inflammation of the uvea. The urea is a part of the eye which can become inflamed and this results in eye redness and pain, sensitivity for light, blurred and or decreased vision and floaters (floating spots in the fields of vision).

In this experimental study the researchers explored whether palmitoylethanolamide (PEA) can protect the eye in a rat model, when the urea is inflamed due to an intoxication: endotoxin-induced uveitis (EIU). EIU was treated by PEA and a second group of animals was treated with control-solution. PEA treatment decreased the intensity of the eye inflammation and also improved the damage of the eye tissues. PEA treatment also reduced all minds of inflammatory molecules such as the tumor necrosis factor (TNF-α) and reduced lipid peroxidation.

PEA also strongly inhibited iNOS expression and nuclear NF-κB translocation, all very specific markers of inflammation.

The authors concluded that in this study PEA reduced the degree of ocular inflammation in uveitis.

PEA protects the eye in uveitis

For pain relief and for inhibiting inflammation, most patients choose:

  • PEA capsules produced in the Netherlands by Russell
  • PEA tablets produced in Italy by Epitech

Palmitoylethanolamide in eye-inflammation: uveitis

Palmitoylethanolamide may therefore be useful in the treatment of such eye inflammations. We prefer to treat either with the Italian PEA tablets, based on PEA-um or PEA-m, or by administrating the Dutch PEA capsules containing PEA-opt. Dutch capsules do not contain any fillers and contain 100% pure PEA in vegetarian capsules.

Only for these the Dutch and the Italian formulations long term safety and efficacy data gathered under the supervision of MDs are available. And only for these formulations (PEA-um, PEA-m and PEA-opt) there are currently data available proving that after intake PEA levels in the body signifi-cantly rise. Such data do not exist for me-too PEA formulations.

In such states of eye inflammation an ophthalmologist needs to treat the condition, and it PEA is added to the treatment we suggest to dose high: 3 times 2 capsule of PeaPure for instance.


Impellizzeri D, Ahmad A, Bruschetta G, Di Paola R, Crupi R, Paterniti I, Esposito E, Cuzzocrea S.
The anti-inflammatory effects of palmitoylethanolamide (PEA) on endotoxin-induced uveitis in rats.
Eur J Pharmacol. 2015 Aug 15;761:28-35. doi: 10.1016/j.ejphar.2015.04.025. Epub 2015 Apr 28.