In an elaborate study in 60 patients suffering from a form of eczema, the asteatotic eczema, dermatologists amongst others from an university hospital in France, Besançon University Hospital, could prove that PEA containing cream could not only reduce skin scaling, redness, itch and dryness, but PEA also improved the biological function of the skin.

“PEA protects the skin and enhances its natural resistance against eczema”

The study was a classical randomized, double-blind, comparative study in 60 patients, half received placebo cream and half the PEA cream. Apart from the clinical relevant symptoms, the study focussed on the biological function of the skin barrier function of the skin and the so called perception threshold. This is a measure for the functionality of the skin, and this is very much disturbed in eczema. The scientists measured these skin parameters at the beginning and after 28 days treatment by clinical scoring and by bioengineering technology to monitor the functionality of the skin.

For pain relief and for inhibiting inflammation, most patients choose:

  • PEA capsules produced in the Netherlands by Russell
  • PEA tablets produced in Italy by Epitech

Impressed by properties of PEA cream

The dermatologist were quite impressed with the properties of the PEA cream, compared with traditional skin creams without PEA! Regular application of a topical PEA cream could indeed improve both passive and active skin functions simultaneously.

Furthermore, the clinical improvement was measured by the dermatologist using the Eczema Area and Severity Index, and this index is very useful in measuring improvement of atopic dermatitis. PEA cream was significantly and clinically much better at improving skin scaling and dryness, and was superior in decreasing itch of the atopic eczema skin.

So PEA cream both improved the biological function of the skin as well as reduced the clinical symptoms of eczema! Side effects were none. The dermatologists highlighted the positive effects of PEA cream on rebuilding the skin neuroimmunoendocrine barrier, a fact not documented for any cream in the past.

The PEA cream containing the highest concentration of PEA is the 1 % PEA cream Russell Science developed in 2012.


Yuan C, Wang X-M, Guichard A, et al. N-palmitoylethanolamine and N-acetylethanolamine are effective in asteatotic eczema: results of a randomized, double-blind, controlled study in 60 patients. Clinical Interventions in Aging. 2014;9:1163-1169. doi:10.2147/CIA.S65448.