Fibromyalgia is a chronic pain syndrome, frequently is present in women (5%) and sometimes also in men. Fibromyalgia leads to muscle pains and stiffness, as well as chronic feelings of fatigue and depression. Often there are also sleeping and bowel disturbances and problems.

Fibromyalgia is a problem of muscles and connective. The connective tissue cannot properly function, neither can the muscle due to shortages of the natural balancing molecule palmitoylethanolamide (PEA). This shortage causes the chronic (muscle) pain is caused.

Fibromyalgia, PEA, and inflammatory mast cells

Since 2005 palmitoylethanolamide (PEA) is used in treatment for fibromyalgia. PEA has natural painkilling and anti-inflammatory properties. Mast cells are inflammatory cells with a special influence on the nervous system and the immune system. PEA regulates the functioning of the mast cells and has inhibited overactive inflammatory reactions. These inflammatory reactions can lead to chronic pains such as in fibromyalgia. Besides that, PEA stops other inflammatory mediators, for instance, TNF-alpha, IL1, and COX-2.

Because PEA stops these inflammations, it also reduces the pain. Because of this, PEA can be quite useful in the treatment of fibromyalgia and chronic pains.

For pain relief and for inhibiting inflammation, most patients choose:

  • PEA capsules produced in the Netherlands by Russell
  • PEA tablets produced in Italy by Epitech

Clinicians explored its effect and found PEA helpful for patients suffering from fibromyalgia.

All preparations that carry the PEA-opt® quality mark contain PEA with the highest level of purity. This is vital because there are various PEA preparations on the market and in some products the level of purity is obscure or low.

Literature on PEA in fibromyalgia

Del Giorno R, Skaper S, Paladini A, Varrassi G, Coaccioli S. Palmitoylethanolamide in Fibromyalgia: Results from Prospective and Retrospective Observational Studies. Pain Ther. 2015 Dec;4(2):169-78. doi: 10.1007/s40122-015-0038-6. Epub 2015 Sep 3.

Palmitoylethanolamide (PEA) – A Medical Food for Fibromyalgia (and ME/CFS?).