In our brain various cell types are important for the optimal function of our braincells. In Alzheimer brains there are a number of disturbances, induced by a pathological protein called beta-amyloid (also referred to as Aβ) This Aβ induces a chronic inflammation in the brain, called astrogliosis , and this can further worsen the symptoms of Alzheimer disease (AD) due to so called proinflammatory and pro-oxidant mediators.

This proces in itself may stimulate other pathological molecules, the so called pro-angiogenic molecules. This induces new little blood vessels to grow, but sadly enough such reaction
exacerbate the cell growth of brain supportive cells, and these cells create a whole wave of inflammation. Than the blood-brain barrier permeability increases and more inflammation starts to occur.

PEA inhibits brain inflammation and overactive vessel formation

The endogenous fatty compound palmitoylethanolamide (PEA), is a very special protective molecule and it has many good effects: anti-inflammatory, anti-pain and anti- excessive blood vessel-growth effects.

Scientists from Italian universities investigated the effects of PEA on the many pathological changes in the brain of Alzheimer. PEA could concentration-dependently reduce inflammatory reactions in the brain, as well as inhibit pro-angiogenic molecules.

PEA treatment inhibited the levels in the nucleus of the braincells of a very specific protein called the ‘mitogen-activated protein kinase 1’ This is one of the most important pro-angiogenic molecules.

It was also demonstrated that PEA acts through the chronic resetting of a specific receptor in the cell nucleus, the ‘proliferator-activated receptor alpha’.

The authors concluded their research stating:

“Collectively, these data support the potential therapeutic utility of PEA in AD.”

PEA Alzheimer disease

For pain relief and for inhibiting inflammation, most patients choose:

  • PEA capsules produced in the Netherlands by Russell
  • PEA tablets produced in Italy by Epitech

Palmitoylethanolamide is more and more referred to as a putative treatment for Alzheimer. We prefer treatment either with the Italian PEA tablets, based on PEA-um or PEA-m, or by administrating the Dutch PEA capsules containing PEA-opt. Dutch capsules do not contain any pharmaceutical fillers and are 100% pure.

Long term safety and efficacy data gathered under the supervision of MDs are available only for these 2 formulations. And only for these formulations (PEA-um, PEA-m and PEA-opt) there are currently data available proving that after intake PEA levels in the body significantly rise. Such data do not exist for me-too PEA formulations.

Dose recommendation: PEA 400 mg 2-3 times daily after a meal.


Cipriano M, Esposito G, Negro L, Capoccia E, Sarnelli G, Scuderi C, De Filippis D, Steardo L, Iuvone T. Palmitoylethanolamide Regulates Production of Pro-Angiogenic Mediators in a Model of β Amyloid-Induced Astrogliosis In Vitro. CNS Neurol Disord Drug Targets. 2015;14(7):828-37.