Fibromyalgia is a relatively common disease; it occurs in about 5% of women and 1% of men. Characteristic of fibromyalgia is a pain in connective tissue and muscles. Another name for this chronic disease is ‘soft tissue rheumatism’.
In addition to muscle pain and muscle stiffness, this syndrome shows symptoms such as (extreme) fatigue, depression, sleep problems, allergies and intestinal complaints.
No clear cause has yet been found in the development of fibromyalgia. As a result, this disease is often denied by doctors and employers.
Too little growth hormone and too little PEA
In people suffering from fibromyalgia, there appears to be too large a production of neurotransmitters and other chemicals. This affects many mechanisms, such as the sleep pattern, the immune system and the way in which pain is controlled. Most symptoms are the cause of a domino effect: one symptom creates the other symptom.
Because the sleep pattern is disturbed, the body is unable to recover sufficiently. This is partly due to a low level of growth hormone, a substance that has a great effect on connective tissue. Connective tissue ensures, among other things, that inflammation and infections can be combated. Because the connective tissue cannot develop well in fibromyalgia patients, there are severe (muscle) pains. Moreover, the synthesis of palmitoylethanolamide, an endogenous painkiller and anti-inflammatory compound is not sufficient!
Mast cells and palmitoylethanolamide
In the last few years palmitoylethanolamide (PEA) has been used more and more frequently in the treatment of fibromyalgia. PEA is known for its analgesic and anti-inflammatory effect. Mast cells are involved in inflammatory reactions. These mast cells have an influence on the nervous system and immune system. PEA regulates the functioning of mast cells and influences inflammatory reactions. The inflammatory reactions can lead to various complaints, such as migraine and neuropathic pain. In addition, PEA inhibits inflammatory mediators, such as TNF-alpha, IL1 and COX-2. Joint pains and nerve pains often lead to inflammation. PEA inhibits these inflammations and reduces pain. Other painkillers often cause side effects, so that after a while the use of this has to be stopped. This is not the case with PEA because PEA does not cause side effects.
In many different studies, PEA appears to be useful in the treatment of fibromyalgia! Always select an optimal formulation, for fibromyalgia it seems that among the capsules containing PEA, the capsules PeaPlex, containing as well PEA as low physiological doses of some selected vitamins B are the best.