Experimental biologists from a number of universities in Italy specialized in inflammation research explored the activity of PEA in cystitis.

Interstitial cystitis or inflammation of the bladder-wall is often referred to as the painful bladder syndrome. This is a nasty problem and a chronic condition with painful voiding, bladder pressure and pain and sometimes even pain in the entire relic area, without doctors knowing what causes this painful condition. This disorder is much more common in women than in men. More than 3 million U.S. women are suffering from pelvic pain and related symptoms such as urinary urgency or frequency. More research into the cause of this disorder is needed, and it seems that palmitoylethanolamide (PEA) can offer some relief.

PEA is an endogenous fatty mediator molecule, and the authors pointed out it is also a plant derived compound with both analgesic and anti-inflammatory characteristics.

The researchers analyzed whether in experimental cystitis there are changes in the levels of PEA or disturbances of the PEA receptors. A further question was whether administered PEA could help against the symptoms of cystitis.

Cystitis was provoked with a chemical compound, cyclophosphamide, and this compound indeed induced pain behavior, bladder inflammation and voiding dysfunction. These classical cystitis symptoms were all associated with increased bladder levels of PEA and changes in various PEA-receptor systems. If one administered PEA pain was reduced, as well as urine voids and bladder damage.

PEA safe and natural treatment for cystitis

For pain relief and for inhibiting inflammation, most patients choose:

  • PEA capsules produced in the Netherlands by Russell
  • PEA tablets produced in Italy by Epitech

“The authors concluded that PEA protects the bladder and reduces symptoms of cystitis.”

PEA protects the bladder

Palmitoylethanolamide may therefore be useful in the treatment of cystitis and may protect the bladder. We prefer treating cystitis or chronic bladder pain with the Italian PEA tablets, based on PEA-um or PEA-m, or with the Dutch PEA capsules containing PEA-opt. Dutch capsules do not contain any pharmaceutical fillers and are 100% pure, in vegetarian capsules.

Only for these the Italian and Dutch formulations long term safety and efficacy data gathered under the supervision of medical doctors are available. And only for these formulations (PEA-um, PEA-m and PEA-opt) there are currently data available proving that after intake PEA levels in the body significantly rise. Such data do not exist for me-too PEA formulations.

Dose recommendations: 3 times daily 400 mg PEA capsules, and after 3 months reduce to 2 capsules daily if symptoms improve.


Protective effect of palmitoylethanolamide in a rat model of cystitis.
Pessina F, Capasso R, Borrelli F, Aveta T, Buono L, Valacchi G, Fiorenzani P, Di Marzo V, Orlando P, Izzo AA.
J Urol. 2015 Apr;193(4):1401-8. doi: 10.1016/j.juro.2014.11.083. Epub 2014 Nov 18.