Around 25 years after the so called amyloid cascade hypothesis, suggesting that the protein amyloid-β in the brain is a protein damaging the fine nervous tissues via chronic inflammation (Hardy and Higgins, 1992), not much happened to help the patient.

Palmitoylethanolamide (PEA) has been explored since the work of the Nobel laureate Rita Levi-Montalcini in the 90s as a naturally occurring lipid inhibiting chronic inflammation.

Italian specialists in neuroinflammatory events discovered the relevance of the anti-inflammatory and neuroprotective activities of the administration of PEA in a sophisticated Alzheimer model.

They were very surprised to find that PEA was able to restore the amyloid-β induced damage in the nerve tissue via a special nuclear receptor (PPAR). They also found that PEA can reverse cognitive deficits induced by the damaging protein.

PEA Alzheimer disease

For pain relief and for inhibiting inflammation, most patients choose:

  • PEA capsules produced in the Netherlands by Russell
  • PEA tablets produced in Italy by Epitech

PEA helps against Alzheimer and restores memory

The scientists summarized their insights:

“These data disclose novel findings about the therapeutic potential of PEA, and suggest novel strategies that hopefully could have the potential not just to alleviate the symptoms but also to modify disease progression.”

We prefer treatment of Alzheimer either with the Italian PEA tablets, based on PEA-um or PEA-m, or by administrating the Dutch PEA capsules containing PEA-opt. Dutch capsules do not contain any chemical excipients and are 100% pure in vegetarian capsules.

Only for these formulations long term safety and efficacy data gathered under the supervision of MDs are available. And only for these formulations (PEA-um, PEA-m and PEA-opt) there are currently data available proving that after intake PEA levels in the body significantly rise. Such data does not exist for me-too PEA formulations.


Palmitoylethanolamide controls reactive gliosis and exerts neuroprotective functions in a rat model of Alzheimer’s disease.
Scuderi C, Stecca C, Valenza M, Ratano P, Bronzuoli MR, Bartoli S, Steardo L, Pompili E, Fumagalli L, Campolongo P, Steardo L.
Cell Death Dis. 2014 Sep 11;5:e1419. doi: 10.1038/cddis.2014.376.