Cancer is terrible. Chemotherapy (anti-cancer drugs) might help. Not always, but there are tumours which are very sensitive for chemotherapy, and melt away like snow in the sun. For instance Kahler’s multiple myeloma, Hodgkin tumors and testicular cancer. But chemotherapy is not without problems. It is toxic for the nerves.

Good news: the natural cell protectant palmitoylethanolamide can protect nerves against the damage induced by chemotherapy.

Reducing side-effects of chemotherapy with PEA

Chemotherapy-induced peripheral neuropathy (CIPN)is one of the side-effects of anticancer drugs. In the past there are no drugs available that could reduce or prevent prevent CIPN. One could only prescribe painkillers such as gabapentine and amitriptyline.

Therefore there is an urgent need to find effective and safe compounds for CIPN.

In this article the authors tested whether the endogenous cell-protector palmitoylethanolamide (PEA) could reduce the results of nerve damage of chemotherapy.

PEA indeed reversed chemotherapy-induced pathological effects.

Repeated administration of PEA could further kill pain without tolerance.

The authors therefore concluded:

“These findings taken suggest that PEA possesses potential to treat peripheral neuropathy in cancer patients undergoing chemotherapy.”


PEA protects nerves by chemotherapy
Palmitoylethanolamide can indeed be used to both protect the nerves before and during chemotherapy against damage, and to decrease pain and neuropathy.

Advise for use of PEA when under treatment with chemotherapy

We prefer treatment administrating the Dutch PEA capsules containing PEA-opt or the Italian PEA-um or PEA-m tablets. Dutch capsules do not contain any chemical excipients and are 100% pure in vegetarian capsules.

Only for these the Dutch and the Italian formulations long term safety and efficacy data gathered under the supervision of MDs are available. And only for these formulations (PEA-um, PEA-m and PEA-opt) there are currently data available proving that after intake PEA levels in the body significantly rise. Such data do not exist for me-too PEA formulations.


Donvito G, Wilkerson JL, Damaj MI, Lichtman AH. Palmitoylethanolamide reverses paclitaxel-induced allodynia in mice. J Pharmacol Exp Ther. 2016 Sep 8. pii: jpet.116.236182.