Palmitoylethanolamide is a new kid on the block since 2005, a natural painkiller, playing an important biological role in diseases with pain and inflammation.

Painkillers are not that safe in general and disrupt many natural functions in our body. NSAID’s such as ibuprofen, diclofenac, and naproxen create great problems for the intestinal system, and tramadol and morphine are painkillers which can confuse you and impair the bowel movements.

Headaches and migraine often are impairing our quality of life. Regular pain medication with substantial side effects is less desirable. Stomach- and intestine tissues can already be affected in a few days of use, and half of all the people that use painkillers often experience stomach and intestinal problems. But it can be much worse. In the US, these simple OTC available painkillers such as aspirin, cost the lives of about 20.000 people each year.

Palmitoylethanolamide: an effective painkiller which is soft for our own body

Even though the best option should be to find the reason behind the pain and to solve it in a natural way, the fight against the pain in the short term is often wanted or necessary to be able to function. Regular painkillers are now not the only option for (chronic) pain complaints. For a couple decennial research has been done on the bodily substance palmitoylethanolamide (PEA). This substance turns out to be the natural painkiller of the body. It plays an important role for pain and inflammation, that often come in pairs.

PEA supports the nervous system.

One of the functions of PEA is the regulation of the functioning of overactive immune and inflammatory cells. Doing this, PEA has a positive influence on the inflammation reactions in the body that have gotten out of hand. These reactions that have gotten out of hand can come from several diseases, ranging from neuropathic pain to migraines. PEA also has a painkilling and anti-inflammatory effect on chronic pain and stops the negative impact of important inflammation molecules, such as TNF-alpha, IL1 and COX-2.

PEA can work as a painkiller for severe back- and hernia pain, endometriosis, shingles, pain due to compression of nerves, such as carpal tunnel syndrome, and pain due to a migraine and menstruation pains.

For pain relief and for inhibiting inflammation, most patients choose:

  • PEA capsules produced in the Netherlands by Russell
  • PEA tablets produced in Italy by Epitech

Dosage and availability of PEA in migraine

Take PEA as 400 mg capsules (look for the capsules with the quality marker PEA-opt), three times a day for 2-4 weeks. After, with good effects, the 400 mg capsules can be taken twice a day. If the pain comes back or does not respond the dosage can be increased to 800 mg three times a day.

The first painkilling effect can happen within a few days to several weeks, however sometimes one has to wait for 6-8 weeks. When after 8 weeks there is still no effect, the substance is probably not effective for this patient and the therapy can be stopped.

PEA is available via the internet as a supplement in 400 mg capsules. Taking pure PEA seems to currently still be the best first option if one suffers from chronic pain or a migraine.

PEA capsules with a PEA-opt® quality mark are PEA formulations that – under the supervision of doctors – are clinically tested for effectiveness and safety.