Palmitoylethanolamide (PEA) is a natural anti-inflammation compound and painkiller, and since 2000 many hundreds of scientific articles have proven its use.

First advice: we always recommend a PEA capsule with the Pea-opt quality label and we do this because capsules with this quality label have a long-standing proof of safety under the supervision of medical doctors. Moreover, these capsules are certified as containing only pure PEA and nothing else. More and more products nowadays are copy-cats and contain palmitoylethanolamide, however not in a patented formulation. Patented formulations, which guarantee adequate plasma levels of PEA after intake, are only produced by the company Epitech (as tablets of 300 and 600 mg) and the company Russell Science (as capsules of 400 mg).

For pain relief and for inhibiting inflammation, most patients choose:

  • PEA capsules produced in the Netherlands by Russell
  • PEA tablets produced in Italy by Epitech

Palmitoylethanolamide is endogenous produced molecule, produced by the cells of our own body, which has both painkilling and anti-inflammatory properties. PEA is produced by almost all living animals and plants, in their own cells and tissues, as a reaction to stress and negative impact, to protect these cells and tissues. PEA not only protects and restores, it also relieves chronic pain and inflammation.

Palmitoylethanolamide (PEA): the work of a Nobel prize winner

Professor Rita Levi-Montalcini won the Nobel prize in 1987, and she also discovered the working mechanisms of PEA in 1993. Since her work in the 90s over 600 scientific publications about PEA have been published, and the compound has been tested in a great variety of clinical studies in the fields of chronic pain and inflammation. PEA was found to be effective and safe. There are no known significant side effects, not interactions. The substance therefore can be taken in combination with other drugs and medications.

A dietary supplement under different brand names: PEA recommendations

Many patients ask us which product is the purest, with proven quality and safe for me to take? PEA is a dietary supplement which you can get in many different forms; we can however not mention the brand names. It is therefore important to know that the purity can be guaranteed by an analysis report, such as for example has been made public by the producer of PEA capsules who are certified with the PEA-opt quality mark. There are however a lot of PEA products on the market that do not have a certificate of analysis on their website, that is not a good sign.

We therefore have a preference to prescribe the purest PEA products, that do not have extra chemical and pharmaceutical additives. PEA-opt products as well as PEA-um and PEA-m, and micro PEA all are quality products.

Palmitoylethanolamide: a protecting natural compound for many purposes

PEA has been studied by many different scientific and clinical groups, in a total of more than 5000 patients. Based on the overview work of a Dutch professor in pharmacology, PEA can be useful for 6 categories of diseases and symptoms: rheumatic pains, pains due to compression of nerves, neuropathic pain states, pelvis pains and more in general in diseases characterized by chronic pain and chronic inflammation. PEA is a molecule that protects and brings a natural balance, not only for humans, but also in animals.

Instructions for the use of palmitoylethanolamide

For the supplement, available as 400 mg capsules we recommend: starting with 3 capsules a day, after a meal. Keep this dosage for 2-3 months. In case of satisfactory effects, you can lower the dose to 1-2 capsules a day. In case of insufficient effects, you can increase it to a double dosage, 3 times 2 capsules, for a period of 1 month.

After 3-4 months you can decide, depending on the effects:

  • To continue taking 1 capsule 2 times a day
  • To decrease the dosage to 1 capsule a day
  • To stop taking the doses.

Each PEA capsule with the PEA-opt® quality mark is produced by means of a patented method so that it is never necessary to add any chemical or pharmaceutical excipients. This means that your body is not burdened by unnatural and foreign substances. PEA-opt® stands for quality, purity and for a standardized and patented production process