Some Key facts on PEA

  • PEA started to be synthesized by sea animals 300.000.000 years ago and provided so many advantages, that nearly all animals now produce this cellular protector
  • PEA is a natural modulating molecule in many animals and in humans, and even in plants
  • PEA repairs and protects against cellular damage
  • PEA is a food component in foods like meat, eggs, soya beans, fish, shellfish and peanuts
  • PEA is produced in the body and creates balance, helping to restore the balance in all tissues, such as the immune system and the nervous system
  • PEA has been discovered as a natural anti-inflammatory molecule in 1957
  • PEA has been discovered as a natural anti-pain molecule in 1975
  • PEA has been used extensively to support immune and nervous functions since the 70s in millions of people

PEA can be used alone or in addition to painkillers and anti-inflammatory drugs

For pain relief and for inhibiting inflammation, most patients choose:

  • PEA capsules produced in the Netherlands by Russell
  • PEA tablets produced in Italy by Epitech

Scientific facts and early quotations on PEA

The biological properties and the structure of PEA were first discovered in 1957 and described in a key paper, bearing the title in:

The identification of N-(2-Hydroyethyl)- Palmitamide as a naturally occurring anti- inflammatory agents.

The authors described PEA as a natural compound and they also demonstrated that PEA is part of food products such as soybean lecithin, egg yolk and peanut meal, from which it can be isolated.

They wrote:

“We have succeeded in isolating a crystalline anti-inflammatory factor from soybean lecithin and identifying it as S-(2-hydroxyethyl)-palmitamide. The compound also was isolated from a phospholipid fraction of egg yolk and from peanut meal.”

Kuehl, F.A.; Jacob, T.A.; Ganley, O.H.; Ormond, R.E.; Meisinger, M.A.P. J.Am.Chem. Soc. 1957, 79, 5577-5578.

Gangley and his colleagues described in 1958 that PEA can decrease the intensity of several inflammatory and immunological processes in animals.

GANLEY, O. E. GRAESLE and H. J. ROBINSON, J. Lab. clin. Med. 57, 709 (1958)

The Nobel price laureate Levi-Montalcini wrote in 1993 about molecules as PEA that they may play a self-reparative role in pathological conditions:

‘Tissue accumulation of free N-acylethanolamine’s has been reported to occur in pathological degenerative conditions. As such conditions are known to be associated with inflammatory reactions, one attractive hypothesis is that the production of these lipidmetabolites may play an autacoid role in controlling mast cell behavior in pathological conditions.’

Aloe L, Leon A, Levi-Montalcini R.A proposed autacoid mechanism controlling mastocyte behavior.  Agents Actions. 1993;39 Spec No:C145-7.

Levi-Montalcini expanded her ideas about PEA in 1995:

‘Conceivably, PEA… might play a role in modulating cellular defense mechanisms ….. The activation …. might down-modulate deleterious cellular processes following pathological events or noxious stimuli in both the immune and nervous systems…..’

L. FACCI, R. DALToso, S. ROMANELLO, A. BURIANI, S. D. SKAPER, Mast cells express a peripheral cannabinoid receptor with differential sensitivity to anandamide and palmitoylethanolamide. Proc. Natl. Acad. Sci. USA Vol. 92, pp. 3376-3380, April 1995