Scientists and fertilization experts from the Endocannabinoid Research Group, Reproductive Science Section, the Centre for Radiation, Chemical and Environmental Hazards, Health Protection Agency and London Women’s Clinic explored the role of palmitoylethanolamide in sperm quality. Sperm quality is a big issue nowadays, as it seems that the quality of human male sperm is rapidly decreasing.

The English fertilization experts explored ninety men attending an infertility clinic for semen analysis and measured PEA levels in the sperm.

Low PEA level in suboptimal spermfluid

Palmitoylethanolamide concentrations in the sperm fluid were clearly much lower in men with complaints of difficulty creating children. The two disorders were less vital sperm and less concentrated sperms. Doctors call those disorders of sperm asthenozoospermia and oligoasthenoteratozospermia. In these men, compared with healthy men measurements via a scientific method called the ultra high-performance liquid chromatography (HPLC)-tandem mass spectrometry indicated a deficiency of PEA. The good news of the study is that the administration of almitoylethanolamide quickly and quite relevant could improved sperm quality, especially the swim-capacity and the time the sperm stays alive, the so called viability.

The specialists concluded:

“Maintenance of normal PEA tone in human seminal plasma may be necessary for the preservation of normal sperm function.”

PEA an innovative treatment

For pain relief and for inhibiting inflammation, most patients choose:

  • PEA capsules produced in the Netherlands by Russell
  • PEA tablets produced in Italy by Epitech

Palmitoylethanolamide may be useful in the treatment of suboptimal sperm quality. We prefer for improving sperm quality either Italian tablets, based on PEA-um or PEA-m, or Dutch capsules containing PEA-opt. Dutch capsules do not contain chemical excipients. Only for these formulations long term safety and efficacy data are available. Only for these formulations there are currently data available proving that after intake PEA levels in the body significantly rise.

We advice 800-1200 mg PEA/daily for at least 6 months in order to optimize the palmitoylethanolamide concentration in the body and in the sperm.


Relationship between seminal plasma levels of anandamide congeners palmitoylethanolamide and oleoylethanolamide and semen quality.
Amoako AA, Marczylo TH, Elson J, Taylor AH, Willets JM, Konje JC.
Fertil Steril. 2014 Nov;102(5):1260-7. doi: 10.1016/j.fertnstert.2014.07.767. Epub 2014 Sep 8.