PLOS One is a special journal for high level scientific communications. Many PEA articles have been published in this journal. In the distant past (80s last century) investigators discovered the protective role of palmitoylethanolamide (PEA) in myocardial infarctions. This lead a number of scientists to explore the antihypertensive properties of PEA in hypertension.

PEA however from our perspective should mot be given alone, but it will protect vessels and heart when given together with a classical anti-high blood pressure pill.

Mechanisms of the blood pressure protective effect of PEA

Palmitoylethanolamide (PEA) has been demonstrated to lower blood pressure and protect kidneys and heart against damage induced by hypertension.

The scientists wanted to study the mechanisms why PEA lowers blood pressure. In order to do so, they selected a number of biological factors important for high blood pressure and explored the influence of PEA on these factors:

1. the molecules ‘epoxyeicosatrienoic acids’,
2. the CYP-dependent arachidonic acid metabolites, and
3. the renin angiotensin system (RAS) modulation.

PEA had numerous protecting effects:

1. it significantly decreased the first factor (the epoxide hydrolase protein level),
2. it reduced the serum concentration of 14-15 dihydroxyeicosatrienoic acid,
3. it down-regulated angiotensin receptor 1 and angiotensin converting enzyme expression,

PEA protects and lowers blood pressure

They concluded:

“Our data demonstrate the involvement of epoxyeicosatrienoic acids and renin angiotensin system in the blood pressure lowering effect of PEA.”

We prefer treatment either with the Italian PEA tablets, based on um- and m-PEA, or by administrating the Dutch PEA capsules containing PEA-opt. Dutch capsules do not contain any fillers and are 100% pure in vegetarian capsules.

Only for these 2 formulations long term safety and efficacy data gathered under the supervision of MDs are available. And only for these formulations (PEA-um, PEA-m and PEA-opt) there are currently data available proving that after intake PEA levels in the body significantly rise. Such data do not exist for me-too PEA formulations.


Mattace Raso G, Pirozzi C, d’Emmanuele di Villa Bianca R, Simeoli R, Santoro A, Lama A, Di Guida F, Russo R, De Caro C, Sorrentino R, Calignano A, Meli R. Palmitoylethanolamide treatment reduces blood pressure in spontaneously hypertensive rats: involvement of cytochrome p450-derived eicosanoids and renin angiotensin system. PLoS One. 2015 May 7;10(5):e0123602. doi: 10.1371/journal.pone.0123602. eCollection 2015.