It is quite well known that palmitoylethanolamide (PEA) can be used together with other painkillers to enhance the efficacy and create a better painkilling effect.

Doctors from the university of Mexico could prove that PEA increases the painkilling effects of a well known painkiller available as OTC (over the counter) painkiller, Acetaminophen, also known as paracetamol in an experimental model for pain.

Acetaminophen is widely used as a painkiller in neuropathic pains, but given alone, its painkilling effects is not that impressive. The pain doctors explored the extra painkilling effects of PEA, given together with acetaminophen in a pain model with diabetic rats The combination between these two painkillers resulted in a measurable and clear synergistic effect.

The authors concluded:

“These results provide evidence that PEA in combination with acetaminophen could be useful for pain therapy in neuropathic diabetic patients.”

Comparable data have been published for the painkiller-enhancing effect of PEA when given together with an opioid.

For pain relief and for inhibiting inflammation, most patients choose:

  • PEA capsules produced in the Netherlands by Russell
  • PEA tablets produced in Italy by Epitech

Palmitoylethanolamide: makes sense together with Acetaminophen to enhance painkilling effects

Palmitoylethanolamide may therefore be useful in the treatment of neuropathic pain when a painkiller as acetaminophen is used. We prefer to boost this painkilling effects either with the Italian PEA tablets, based on PEA-um or PEA-m, or by administrating the Dutch PEA capsules containing PEA-opt. Dutch capsules do not contain any chemical excipients and are 100% pure in vegetarian capsules.

Only for these the Dutch and the Italian formulations long term safety and efficacy data gathered under the supervision of MDs are available. And only for these formulations (PEA-um, PEA-m and PEA-opt) there are currently data available proving that after intake PEA levels in the body significantly rise. Such data do not exist for me-too PEA formulations.


Déciga-Campos M, Ortíz-Andrade R.
Enhancement of Antihyperalgesia by the Coadministration of N-palmitoylethanolamide and Acetaminophen in Diabetic Rats.
Drug Dev Res. 2015 Aug;76(5):228-34. doi: 10.1002/ddr.21259. Epub 2015 Jul 27.

Déciga-Campos M, Ramírez-Marín PM, López-Muñoz FJ.
Synergistic antinociceptive interaction between palmitoylethanolamide and tramadol in the mouse formalin test.
Eur J Pharmacol. 2015 Oct 15;765:68-74. doi: 10.1016/j.ejphar.2015.08.025. Epub 2015 Aug 19.