In the old book ‘Erythroxylon coca: a treatise on brain exhaustion, as the cause of disease” by W. TIBBLES, MD. A disorder is described we do not recognize anymore: brain exhaustion.

Dr. Tibbles believed coca leaves is the remedy of choice….

Brain exhaustion was a special case of nervous exhaustion, states of the nervous system we now know that those are probably related to slow inflammation. For symptoms of tiredness, irritability, lack of energy, chronic pain in the past doctors could only diagnose these as ‘exhaustion’.

Why palmitoylethanolamide is used.

Nowadays we know much more. For such states, the natural anti-inflammatory compound and supplement palmitoylethanolamide (PEA) seems quite a good fit.

Many patients suffering from chronic fatigue syndrome have benefited from PEA (eg. 2-3 times daily 400 mg). Patients often prefer the PeaPlex capsules, because the biological and physiological normalizing action of PEA has been supported by a special selection of low dose vitamins of the B group, suited to support the immune system and the nervous system.

For pain relief and for inhibiting inflammation, most patients choose:

  • PEA capsules produced in the Netherlands by Russell
  • PEA tablets produced in Italy by Epitech

Here we disclose an old text on brain exhaustion, part 8,

third and last part of chapter 2, amongst others on tobacco.


Dr. Hutchinson, a most eminent surgeon in London, in a communication which he made to the Royal MedicoChirurgical Society, mentioned several cases where syphilis had been communicated by vaccination, and about which there could be no mistake. Thirteen adults were vaccinated from the arm of an infant, which was, as far as external appearances could lead, apparently healthy. Five weeks after the operation eleven of these individuals were affected with well-marked syphilitic sores. I am personally acquainted with a case in which the following are the particulars. The father at first refused to allow the child to be vaccinated but afterward consented, having been once fined for his previous refusal, after a week or two, the following symptoms appeared: languor, debility, and then little black spots appeared on his thighs and back, which presented a most shocking appearance. The surgeon who had vaccinated the case gave it as his opinion that syphilis had been communicated to the child through vaccination. Dr. Hitchman says, ” As a public vaccinator, I repeat that hundreds of men, women, and children have been poisoned by means of four or five punctures, yet none of them took, as the phrase is, in form of a distinct vesicle, having an elevated edge and depressed center — significant of small-pox, and distended with a clear lymph or ‘ pure matter.’ What is the issue of lifelong experience?

On either arm of the child were not visible, as an invariable rule, four or five ugly scabbed ulcers, larger than shillings, with dusky red indurated margins; but, as damming substitutes for their conspicuous absence, came an intractable bubo in the corresponding axilla, a hideously sunken bridge to each syphilitic nose, sores about the arms, inflamed eyes scaly diseases of the skin of a copper color, with a tendency to everlasting ulceration, or recurrent excoriations, specially baldness, groups of tubercles, ay, dirty yellow, or nasty brown stains, ulcers on the tonsils, morbid action in the bones, with an irresistable tendency to scrofula, consumption, or ‘ water in the head,’ &c Such is the propagation of syphilis by vaccination!”

Mr. Shaw says, “I have known most fearful convulsions brought on by it, and that in children appear in the firmest health.”

Vaccination as a preventative failed.

The attempts to prove the value of vaccination as a preventative, or mitigator of small-pox, having one and all signally failed, and seeing that many most loathsome and dangerous diseases may be communicated by the process, we contend that the compulsory clauses of the Vaccination Act should be forthwith repealed. Those who wish to be vaccinated, by all means, let them have all the protection the process is capable of conferring upon them. If they are proof against contagion as they suppose themselves to be, they can have nothing to fear from their unvaccinated neighbors. “We believe that in a careful observance of the laws of hygiene alone, can we find safety from the incursions of this loathsome disease. Small-pox, like all other zymotic diseases, may be stamped out by the use of pure oxygenated air, pure water, wholesome food, unadulterated drink, proper clothing, sufficient exercise, frequent bathing, better drainage, no alcohol, no tobacco, in a word, cleanliness, and regular moral and mental culture.

Produce disease.

The excessive employment of strong medicines has a tendency to produce disease; thus, drastic purgatives will bring on hemorrhoids or piles; mercury will hasten the process of consumption, produce disease of the bones; excessive use of the alkalies will irritate the digestive mucous membrane, so with acids; and all narcotics will obtund the sensations and cloud the intellect. There is the strongest reason to believe, that many nervous affections are exasperated by the habitual use of mercurial purgatives, as blue pill; iodine has sometimes caused more obvious nervous irritations; the nitrate of silver produces a permanent disease of the skin, limited, however, to an affection of its color.


Smoking, etc., op Tobacco. — The use of tobacco which has become so generally prevalent in this country, where we see boys, ranging in age from fourteen years, with either a short pipe or a cigar. They either snuff or else they chew the weed. The same habits prevail to a great extent over the whole surface of the globe.

“When we take into account the disagreeable and repulsive character of this article to the palate in its natural state, it is truly surprising that it should ever have been thought of as an article to be used in the manner that it now is; and when to this is added the exceedingly important consideration that it is very injurious to health and cleanliness, it is the more astonishing. It should be clearly understood that tobacco is an actual and virulent poison. Four drops of the essential oil of tobacco is a sufficient quantity to produce violent convulsions and death in very few minutes. Two drops are sufficient to destroy a dog. The essential oil — the principle of which is nicotine, is contained in the smoke, the amount varies according to the quality of the tobacco, and during the process of smoking it is by no means dissipated into the atmosphere, but is carried by the smoke into the mouth of the smoker; it is found that 4,500 grains of tobacco smoke yields no less than thirty grains of this nicotine. Tobacco is of so uncongenial nature and has such a baneful influence, that it is seldom used medicinally, even in the most desperate cases. In many_ instances where it has been administered internally, or even externally, it has produced the most terrible symptoms. I once knew a reverend gentleman who suffered from tooth-ache, which was of such an intractable nature, that it would not yield to any remedy that had been used. It was decided that the essential oil of tobacco should be tried; accordingly, the point of a fine needle was dipped into some of that substance and applied to the tooth; the nerve being bare its action was immediate; the effects produced were sick-ness, diminished action of the heart, trembling of the limbs, afterwards insensibility, and, in fact, he presented all the appearance of a man who had been drinking until he was dead drunk. A tobacco poultice applied over the region of the stomach produces the most terrible vomitings.

Its application to the head produces similar effects.

Smoking effects digestion.

An individual with smoking draws off nature’s first and greatest agent which is employed in digesting the food necessary for the nourishment of the body. This is likewise affected by the process of chewing. Darwin (Zoonomia) says: — ” The unwise custom of chewing and smoking tobacco for many hours in the day not only injures the salivary glands, producing dryness in the mouth when this drug is not used, but I suspect that it also produces scirrhus of the pancreas. The use of tobacco in this immoderate degree injures the power of digestion, by occasioning the patient to spit out that saliva which he ought to swallow; and hence produces that flatulency which the vulgar unfortunately take it to prevent I saw, what I conjectured to be a tumour of the pancreas and indigestion, which terminated in the death of the patient. He had been for many years a great consumer of tobacco . . .”

The effects of tobacco.

Smoking and chewing not only carry off saliva from its proper place, but they likewise saturate the tongue and mouth, so that what saliva is secreted after the operation of either process, is contaminated with the juice of the drug, which saliva in this pernicious and poisonous condition finds its way into the stomach; and who can wonder, in view of these considerations, that tobacco fixes its deadly grasp upon the various vital organs of the body, gradually undermining the health, and disseminating the seeds of disease, which only awaits a suitable opportunity to make itself manifest.

The action of tobacco is directly upon the nervous system, enfeebling, exhausting, or destroying the powers of life. No fact is better known to medical practitioners than that tobacco has great influence in producing impotence. This is owing to its depressing action on the nerves. It acts first on the brain and nerves, and then on the various muscles. When the nerves of the heart and stomach have been, by the long depressing influence, lowered in their power, in consequence of the diminished power of the heart, digestion which produces the blood is impaired, and consequently, the various muscles of the sexual organs are impaired. It is especially liable to diminish the sensibility of the lining membrane of the mouth, nose, and stomach, and by enfeebling the nervous power of the latter organ, instead of promoting digestion, as its supporters urge, it has a direct tendency to produce indigestion, with all its subsequent symptoms. The dryness of the mouth produced, thus creating a thirst, which in many cases is not satisfied with anything short of alcoholic drinks. In this way the use of tobacco is a frequent fore-runner or associate of drunkenness.

Tabacco and bad habits

The use of tobacco by boys produces a state of nervous excitability, which renders them peculiarly susceptible of lustful dreams and amorous fancies which seek their gratification in secret bad habits, now so prevalent among the youth of this country.

All consumers of tobacco, at once and for ever exist ! For the sake of your health, property, time, friends, voice, and memory.

I have known several who for their great attachment to the pipe have been led into drunkenness, poverty, and crime.

But some may say, ” I only take a little pipe or a cigar now and then, to please others,” then you may soon be as great a slave to it as others are. When it is offered to you, refuse it. Touch not one particle of the horrid drug, and you will never regret the position you take. I consider the use of tobacco at once excessively injurious to the organs of the body and mind.


  1. Tibbles (1859-1928) Erythroxylon coca : a treatise on brain exhaustion, as the cause of disease, 1877, Helmsley : W. Allenby ; Leeds : Joseph Dodgson ; Leicester