In the old book ‘Erythroxylon coca: a treatise on brain exhaustion, as the cause of disease” by W. TIBBLES, MD. A disorder is described we do not recognize anymore: brain exhaustion.

Dr. Tibbles believed coca leaves is the remedy of choice….

Brain exhaustion was a special case of nervous exhaustion, states of the nervous system we now know that those are probably related to slow inflammation. For symptoms of tiredness, irritability, lack of energy, chronic pain in the past doctors could only diagnose these as ‘exhaustion’.

Why palmitoylethanolamide is used.

Nowadays we know much more. For such states, the natural anti-inflammatory compound and supplement palmitoylethanolamide (PEA) seems quite a good fit.

Many patients suffering from chronic fatigue syndrome have benefited from PEA (eg. 2-3 times daily 400 mg). Patients often prefer the PeaPlex capsules, because the biological and physiological normalizing action of PEA has been supported by a special selection of low dose vitamins of the B group, suited to support the immune system and the nervous system.

For pain relief and for inhibiting inflammation, most patients choose:

  • PEA capsules produced in the Netherlands by Russell
  • PEA tablets produced in Italy by Epitech

Here we disclose an old text on brain exhaustion, part 7,

The seccond part of chapter 2, among which stimulating drugs. Furthermore, a very interesting part on vaccination!

Stimulating condiments.

These condiments excite a false appetite and induce us to eat too much, and false appetite, and induce us to eat too much, and depression follows. Tobacco is a virulent poison, and, therefore injurious. No doubt the after-dinner cigar excites secretion and stimulates digestion — so does the glass of brandy. But by this very excitement, they gradually weaken and exhaust the nervous system. For what is borrowed in this way, we pay very heavy interest.

It is worthy to be remarked, that not only do excess in diet, and extreme abstinence, too much rest and excessive fatigue, extremes of heat and extremes of cold, disorder the body; but that they all seem when carried to the utmost to affect the body in the same, or nearly the same manner.

All by eventually inducing those disturbed actions, which constitute impairment, or disease of the nervous or vascular systems. In fact, what is called reaction, under most circumstances, consists of febrile or inflammatory processes; and conversely, namely, that inflammations and fevers, are probably intended to rid the body of some inconvenience some effete matter.

Mental Causes

The great gift of the mind, which affects its operations on the body through the medium of the Brain and nervous system, by which man is so raised above the lower animals — by which he enquires, improves, records his improvements, and looks beyond this life — is a gift that his imperfect nature cannot bear without the tribute of occasional inconveniences, from which the less privileged animals are exempt. Its inordinate action, and its vehement impressions of which it is susceptible, exhaust the nervous energy, or impair the nervous actions, or alter the actual condition of the nerves; and thus deprive the physical part of the system of some of its power, increase its susceptibility, disturb the process which should be performed in the different bodily organs, and bring on disease, or gradually enfeeble the whole system. From such causes, we perceive, in different cases, various irregular actions,— agitation, trembling, faltering voice, unsteady gait, spasm, indigestion, hysteria, epilepsy; or exemplifications of diminished power, as in various forms of paralysis.

By sloth and negligence, or by irregularity and prodigality of application, the powers of the mind itself are equally impaired in some cases, and in others disturbed.

Sudden and excessive joy exhausts the mental and nervous powers at once; and sudden and overwhelming sorrow oppresses both, producing a state which is followed by that deep sleep which restores the capacity of endurance, and sometimes, by that sleep which ends all worldly suffering.

We seem to be weaker than our grandfathers.

Herbert Spencer says, ” It is asserted by not a few, that among the educated classes the younger adults and those who are verging on maturity, are neither so well grown nor so strong as their seniors. On first hearing this assertion, we were inclined to class it as one of the many manifestations of the old tendency to exalt the past at the expense of the present. Calling to mind the facts that, as measured by ancient armor, modern men are proved to be larger than ancient men; and that the tables of mortality show no diminution, but rather an increase in the duration of life; we paid little attention to what seemed a groundless belief. Detailed observation, however, has shaken our opinion. Omitting from the comparison the laboring classes, we have noticed a majority of cases in which children do not reach the stature of their parents: and, in massiveness, making due allowance for difference of age, there seems a like inferiority. Medical men say that nowadays people cannot bear nearly so much depletion as in times gone by. Premature baldness is far more common than it used to be, and an early decay of teeth occurs in the rising generation with startling frequency. In general vigor, the contrast appears equally striking. Men of past generations, living riotously as they did, could bear more than the men of the present generation, who live soberly, could bear. Though they drank hard, kept irregular hours, where regardless of fresh air, and thought little of cleanliness, our recent ancestors were capable of prolonged application without injury, even to a ripe old age; witness the annals of the bench and the bar. Yet we who think much about our bodily welfare; who eat in moderation, and do not drink to excess; who attend to ventilation and use frequent ablutions; who make annual excursions, and have the benefit of greater medical knowledge; we are continually breaking down under our work. Paying considerable attention to the laws of health, we seem to be weaker than our grandfathers, who in many respects defied the laws of health. And judging from the appearance and frequent ailments of the rising generations, they are likely to be even less robust than ourselves.

” What is the meaning of this? Is it that past overfeeding, alike of adults and children, was less injurious than the under-feeding to which we have adverted as not so general? Is it that the deficient clothing which this delusive hardening theory has encouraged is to blame? Is it that the greater or less discouragement of juvenile sports, in deference to a false refinement, is the cause? From our reasonings, it may be inferred that each of these has probably had a share in producing the evil. But there has been yet another detrimental influence at work, perhaps more potent than any of the others — we mean excess of mental application.”

“Causes of the degeneracy of mankind.”

The influence of sudden mental impressions on the circulation, in whatever way this is exerted, is evident enough in numerous instances. Their power in the production of that unequal distribution of blood called determination is conspicuously seen in the simple act of blushing. Violent anger, or a sense of shame, causes the smaller vessels of the head and face to be instantaneously suffused with blood. By similar, but more violent effects, anger has led to apoplexy; and this passion is seen to render the face red in some individuals and white in others. Fear commonly produces paleness, and extreme fear may induce death. The functions of the lungs may be affected, or at least the respiratory exertions are quickened, by surprise or similar emotions; and simultaneous palpitations show that the heart responds to the same influences; or its sympathy may produce some suspension of its actions, and syncope or fainting ensue: the faltering speech and trembling limbs on some occasions, and the increased speed and strength exhibited on others, equally show how the muscular energy may be influenced by temporary states of the mind. The gushing of tears in states of sorrow, diarrhea and copious urinal secretion under the action of fear or vexation: the sudden appearance of gout and of cutaneous eruptions in circumstances productive of great mental disturbance; the profuse perspirations, and the altered color of the hair sometimes induced, are all illustrations of the operations of the same class of causes.

Long continued depression of mind, long continued anxiety, or long continued discontent, produce effects which are deeper and less immediately visible. The nervous and vascular system seems to suffer equally; and habitual disorder of some of the functions, going on to the structural alteration of some organ, is the consequence. Chronic determination of blood to the vessels of the stomach or lungs, or to the liver, or intestines; or to the heart, or to the brain itself, are common results. Obstinate dyspepsia, attacks of asthma, permanent mischief to the Liver or intestinal functions, or some mental disorder, are among the modes in which such results are manifested: as is also a slow increase in the size or change in the structure of the heart itself; curiously according with that strong and melancholy expression, that the person thus destroyed has “died of a broken heart.”

On the other hand, need anyone be informed of the happy effects of a tranquil state of mind, or of the improved health which is secured by complete relief from heavy anxiety, or the blessedness of real contentment? For there is a jewel which no Indian mine can buy,

No chemic art can counterfeit, It makes men rich in greatest poverty, Makes water wine, turns wooden cups to gold, The homely whistle to sweet music’s strain, Seldom it comes, too few from heaven sent, That much in little — all in naught — Content. — Wilbye.

Diseases are sometimes produced by a disordered imagination.

Some time ago, a patient in one of our hospitals, died from small-pox; another man, in a healthy condition was told that he would have to sleep in the bed in which the small-pox patient had died; he was put to bed, but not in the bed which the man had died, but in a perfectly clean bed in a good ventilated room, he not knowing the change ; the effect produced was such that the man began to suffer from pains in the back, and all the other characteristic symptoms of small-pox, and of such a severe nature, that he speedily died. In this case, it is clear that the man died by disease brought on by the imagination that he was put into a bed in which a small-pox patient had died, whereas he was put into a perfectly distinct room and bed.

It is recorded that in a Bristol infirmary, a number of servant girls, mostly well conducted and respectable, were in one of the wards, and whenever any one of these girls had an attack of hysteria, the other girls were sure to follow with similar fits. Hysteric fits are generally brought on by anything that affects the imagination or the feelings, women are more easily attacked than men, the latter have generally a less mobile nervous system, and are more influenced by the intellect, but they are, nevertheless, sometimes attacked. There is an instance that took place some years ago, which may be here mentioned. In this case, a young girl was attacked with a very violent convulsive fit, brought on by alarm, consequent upon one of her companions putting a mouse down the inside of her dress. The girl had great antipathy to mice, and the sudden shock threw her into this fit; other girls very soon passed off into similar fits; and afterward there got to be an imagination in the minds of the work people, that these fits were produced by some emanations from a bale of cotton, and the consequence was that they spread, till scores of the young women were attacked day after day with these violent fits. The medical man who was called in saw at once the state of things; he assured them in the first place that it was all imagination, that there was nothing in the cotton; and in the second place he administered as a remedy a few violent shocks from an electrical machine, which he assured them would do no harm, but would cure them. And cure them it did. There was not another attack in the place afterward. Dr. Darwin speaks of the inmates of a Nunnery who were all afflicted, one after the other, and at length altogether, with a desire to imitate the inharmonious nocturnal sounds of cats.

The education of young women is very defective; a mother would be in sad despair if her daughter did not give early indications of what is called acute sensibility, and nothing is neglected that may endow her with this gift; there is inaction of the muscular system; cultivation of music; frequent parties, balls, and public entertainments; the understanding unemployed, or books read, which excite certain unhealthy feelings, and nourish illusions — such are the different influences to which girls are subjected at an age, when the mind should have quite a contrary direction, and its powers should be devoted to the obtaining of an accurate knowledge of the necessary duties of domestic life, the one order of faculties is alone exercised, — improper expectations, vain rivalries ; these will become predominant over the reasoning faculties, and produce a host of vapourous, hysterical, hypochondriacal, and maniacal disorders.

To support and resist the disease.

There is a principle in the human body which enables it, when not previously disordered, to support and resist the influences of all the agents of disease up to a certain point. By this principle, great, and even sudden changes in temperature are able to be endured, and the body is secured for a time against the effects of the noxious atmosphere of our cities and towns; but,

“Ye who amidst thia feverish world would wear A body free from pain, of care a mind, Fly the rank city, shun its turbid air ; Breathe not the chaos of eternal smoke, And volatile corruption from the dead, The dying, sickening, and the living world, Exhaled to fully Heaven’s transparent dome With dim mortality.” — Dr. Armstrong.

Great variety and likewise great quantity of food may be taken, when in health, without inconvenience or permanent uneasiness. So also exercise may be taken, even to the production of extreme fatigue, or we may devote ourselves to long continued study, and yet remain well for a time, and it is familiarly seen that neglect of proper rest often passes unpunished. When we are in perfect health, the various trials met within the world ; the joys, the sorrows, the anxieties, which by turns affect us, are met with steadiness and fortitude, and pass away without disturbing, permanently, the equilibrium of that part of the system on which they make their transient impression.

Creating a disease.

But when, by the prolonged or inordinate impression of some of the causes of disease already enumerated, or by other causes of disease which remain to be mentioned, the vital power is impaired in any one organ; when, for instance, the digestive, respiratory, or cutaneous (skin) functions, or the faculties of the mind, begin to show a little interruption of vigor and regularity, even the ordinary objects with which the special function is habitually concerned become exciting causes of disease. In short, all those things which have occasionally been defined as the sources of vital motion, — all external stimuli, all ideas of the mind, and volition, — they become causes of actual disease.

The cure for disease can produce other diseases.

It is not to be forgotten, moreover, that the means employed FOR THE PREVENTION AND CURE OF DISEASES are not always guiltless of producing others. Vaccination, which was put forth by Dr. Jenner as a preventative of small-pox, has not only failed to stamp out that disease, but it is found that by the operation, a number of the most loathsome diseases may be transmitted by the matter put into the child’s arm. I have met with scores of cases, where the health of the child has been completely ruined by this operation.

What is Vaccination?

Let us here pause for a few minutes to inquire “What is vaccination? ” Well, in the year 1775, Dr. Edward Jenner, a general practitioner of medicine, in Gloucestershire, whilst engaged in inoculating with small-pox, observed that the virus had no effect on a number of persons. On inquiry, he learned that they, in common with others in the same neighborhood, considered themselves to be protected from small-pox, by virtue of having had an attack of cow-pox, contracted during the operation of milking the cows. Impressed with the circumstance, the most carefully made observations and inquiries, which confirmed in him the belief that in cow-pox he had a direct antidote to the small-pox poison. Twenty years afterward, May 14th, 1796, he tested it by vaccinating one James Phipps, with matter taken from the hands of a female, who at this time was suffering from cow-pox. On the first day of the following July, Dr. Jenner inoculated Phipps with the small-pox virus, which took no effect, convinced the doctor that his belief had a foundation in fact. He collected more evidence in support of his views, and in the year 1798, published an essay, entitled “An Enquiry into the causes and effects of the Varolse Vaccine: a disease discovered in some of the Western counties of England, particularly Gloucestershire, and known by the name of the cow-pox.” In his essay, Jenner states ” that cow-pox is communicated to the cow from the horse, where it appears on the heels, and is known by the name of the grease, the hands of farm-servants and milkers being the medium of communication.” In 1800, he expressed his conviction that “the cow-pox is capable of extirpating small-pox from the earth.” In his fourth work, published in May 1801, he concludes thus, ” that it is now too manifest to admit of controversy, that the annihilation of small-pox, the most dreadful scourge of the human species, must be the final result of this practice.” The new antidote took amazingly, and thousands were vaccinated. In 1802, a committee of the House of Commons reported upon the practice; and upon Jenner’s claims as the discoverer, whereupon Parliament voted him £10,000, which was afterward (in 1807) increased to £30,000; and in 1808, the Government took vaccination under its care. Small-pox not being prevalent for some time, vaccination was considered to work marvelously; but after a few years, in spite of Jenner’s new antidote, and in defiance of its protectors — the Government — small-pox again appeared, and in 1825, the slain numbered 1,300 persons, among whom, horrible to say, ” were several who had been vaccinated.” Further vaccinations and re-vaccinations were so powerless against the foe, that in 1838, Dr. Gregory stated, ” That the admission into the Small-pox Hospital, more than doubled the average number received annually, prior to the discovery of vaccination.”

Influence of vaccination was of limited duration only.

But no failures appear to have been sufficient to check the zeal of its advocates. Sir Gilbert Blaine wrote, ” It is demonstrable that if at the first moment of this singular discovery, at any moment since, at the present or any future moment, mankind were so wise and decided to vaccinate, the whole human species who have not gone through the small-pox, from that moment would this most loathsome and afflicting of all the scourges of humanity be, instantaneously and forever banished from the earth.” But, alas ! the bombastic declaration of the baronet, received in a few years such a decisive contradiction, that the advocates of vaccination were compelled to examine the causes of failure. The result was, that they broached the theory that the protective influence of vaccination was of limited duration only, and that to ensure the complete annihilation of small-pox, it was necessary that the operation should be repeated. Accordingly re-vaccination was recommended, and practiced to a considerable extent; but yet, case after case of small-pox supervened upon vaccination at so recent a period, that its power of protection could not have been impaired by age. This explanation is found unsatisfactory, it was discovered that to render the system proof against the small-pox poison, one vaccine vesicle, one prick with the lancet, was insufficient. Two vesicles were then recommended, then three, and now we have reached to five. Yet, despite all these precautions, the malady insisting upon making its appearance occasionally, the enthusiastic admirers of Jenner’s antidote, lacking not in their zeal, applied to Parliament for, and actually obtained an Act, making it compulsory, under pain of fine or imprisonment, on every parent to procure the vaccination of his child within three months of its birth. That Act is in active operation to this day. In every district ” vaccination stations” are established, and a no less sum than £350,000 is expended annually for performing parochial vaccination.

The Act is being rigidly enforced, vaccination is thoroughly carried out in almost every part of the kingdom, and was it only possessed of but a small amount of the efficacy ascribed to it by its advocates, small-pox would be almost unknown, except among the unvaccinated.

Vaccination doesn’t always work.

We have shown that, according to Jenner and his supporters, small-pox should, if vaccination possessed the power ascribed to it, be “forever banished from the earth.”

Oh, indeed, Sir Baronet I But, what are the facts? After the above splendid (?) illustration of the prophylactic value of vaccination was the small-pox no more seen or was its virulence any the less ? Do not suppose it. The plague — small-pox, like a destroying angel, remained stationary for a time, and then descended in the very midst of all this “stamping out ” by horse-grease blood-poisoning — so-called vaccination. It is a fact, that the vaccinated are more liable to the small-pox than their unvaccinated neighbors; of this, I have had an abundance of evidence. During a late epidemic of small-pox in the town of Leicester, and in one of the streets of this town every person in every family was vaccinated, and some of them re- and re-re-vaccinated, with one exception, the excepted family, consisting of the father and mother with six children, all of whom were unvaccinated; during this epidemic, every individual of the vaccinated families in the street, had the small-pox, some of them having it in its worst — confluent — form, a number of whom died during the attack; whereas, every individual of the one wM-vaccinated family entirely escaped from the disease. Hundreds of similar instances might be quoted, but would occupy too much of our space. The following occurred in ray own family: during the epidemic of small-pox of 1871, my children, three of whom (the eldest) are vaccinated, and the others were unvaccinated. The vaccinated ones took small-pox, and had it very severely, my two unvaccinated children likewise had it, but in a very mild form; they were all suffering at the same time; the vaccinated ones commenced the disease in the family, and were a much longer time in recovering from it than were the unvaccinated ones. Just one other example of its protective (?) power, and then we will pass on.

One of my neighbor’s, on the appearance of small-pox in the town, determined that he would have himself, wife, and son re-vaccinated, they were immediately operated upon by their own private practitioner, in order to ensure the use of what they called “pure lymph” in the course of four or five days, the husband’s arm began to swell, and at the end of the week, erysipelas set in, very acutely ; the doctor was called in, and he treated the case for some three months before the man was able to resume his ordinary duties. On the tenth day after vaccination, the son caught the small-pox; the case proved to be of such a virulent nature, that it was with great difficulty that anyone could be found to attend to him during his illness; the surface of his body was one complete mass of malignant and putrescent eruption. It was found during the last epidemic of small-pox, that 84 per Cent, of the patients, admitted into the London Small-pox Hospitals had been duly ” protected,” while in Marylebone, no less than 92 per Cent, of the small-pox patients were vaccinated. The Registrar General has shown, that as age increases, liability to small-pox decreases. Of children under five years of age, he found that 10 per Cent, died of the disease; above five and under twenty, 3 per Cent. ; above twenty and under forty, 2 percent. ; and above forty and under sixty, less than 1 percent., at once showing, that the less they were under the influence of vaccination, the less liable were they to the attack of small-pox, or, that the greater mortality occurred under the age of seven, at which time vaccinators hold that the operation loses its effects. Dr. Keller (chief physician to a railway company in Germany) gives the following statistics. In 1872, there came under his notice five hundred and seventy-three cases of small-pox amongst the company’s servants, or members of their families. Of these, the number of eighty-four died, or 14.66 percent. Three hundred and twenty-two of the whole number had been vaccinated; one hundred and ninety-seven had not been vaccinated. The doctor found the mortality, at different periods of life, among the vaccinated and unvaccinated, to be respectful as follows, namely: — from two to three years of age, 30 percent, of the vaccinated died, of the unvaccinated only 19 percent, died, from three to four, vaccinated died at the rate of 15 per Cent, unvaccinated 9 per Cent, only; from four to five, 14 percent. of vaccinated, and but 10 per Cent, of the unvaccinated, died; from five to ten, 11 per Cent, vaccinated died, of unvaccinated 9 per Cent. ; from ten to fifteen, the vaccinated died at the rate of 8 per Cent., unvaccinated 7 percent, died from the disease — small-pox.

Reasons why vaccinated people still got sick.

It was said, by some doctors, that persons who had been vaccinated and yet took the small-pox, that they did so either because the lymph was impure, or else that the operation had been improperly performed. What did they mean by pure lymph? Where did they get it? It was taken from the arm of one child and put into the arm of another. Well, and from what source did they obtain it? From the arm of another child. And so we might trace it until we got to Jenner’s cow and the grease of the diseased horse. But it is not possible to tell if the child, from which the lymph is taken, is a healthy child or not. There are many diseases which might not appear in the lifetime of the child but would do so in the grandchild. It is impossible to tell whether a child was properly healthy or not. How was it possible for them to tell what had been settling in the blood of progenitors for seventy years or more? What diseases had been picked up during that period? And seeing that the so-called “pure lymph” has its origin in the greasy heels of the horse, and as grease is an unmistakable evidence of lung disease, the matter in the heels and that in the lungs, corresponding in every respect, it cannot be doubted that a large amount of the increase in the number of deaths from consumption and other chest diseases, are to a great extent due to the so-called protection afforded by vaccination. It has been proved over and over again, that syphilis has been communicated by vaccination.


  1. Tibbles (1859-1928) Erythroxylon coca: a treatise on brain exhaustion, as the cause of disease, 1877, Helmsley: W. Allenby; Leeds: Joseph Dodgson; Leicester