In the old book “Erythroxylon coca: a treatise on brain exhaustion, as the cause of disease” by W. TIBBLES, MD. A disorder is described we do not recognize anymore: brain exhaustion.

Dr. Tribbles believed coca leaves is the remedy of choice….

Brain exhaustion was a special case of nervous exhaustion, states of the nervous system we now know that those are probably related to slow inflammation. For symptoms of tiredness, irritability, lack of energy, chronic pain in the past doctors could only diagnose these as ‘exhaustion’.

Why palmitoylethanolamide is used.

Nowadays we know much more. For such states, the natural anti-inflammatory compound and supplement palmitoylethanolamide (PEA) seems quite a good fit.

Many patients suffering from chronic fatigue syndrome have benefited from PEA (eg. 2-3 times daily 400 mg). Patients often prefer the PeaPlex capsules, because the biological and physiological normalizing action of PEA has been supported by a special selection of low-dose vitamins of the B group, suited to support the immune system and the nervous system.

For pain relief and for inhibiting inflammation, most patients choose:

  • PEA capsules produced in the Netherlands by Russell
  • PEA tablets produced in Italy by Epitech

Here we disclose an old text on brain exhaustion.

In the preface the author stipulates how important this book on brain exhaustion is:

‘This work is brought out at the urgent request of a large number of my patients and friends. The principles enunciated herein are the result of study and practice conducted during a long series of years, as I assure the reader, an unwavering and earnest desire to benefit my fellow creatures. The principles laid down may be at variance with received notions; yet, if the reader, untrammeled by all pre-acknowledged dogmas, carefully studies those principles and the applications of them, he will come to the conclusion that they are right. Extended experience has demonstrated to myself that the regular system of medicine, if honestly, and disinterestedly considered, is, to say the least, empirical — a destroyer of the vital forces of the patient, — and that the only sure means of restoring diseased persons, is by aiding nature in her efforts to regain an equilibrium of action, by increasing the quantity of nervous energy, or vital force. This is my distinctive and fundamental principle which is in direct accordance with physiological and pathological laws. Perfection is not claimed for this Book; but, conscientiously my aim has been to render the best possible information upon the cajis^s and treatment of disease, and to furnish the public with such information as can be acted upon by anyone who has the management of children or adults.

In the words of Southey I now dismiss this volume :

“Go little book, from this my solitude: I cast thee on the waters. Go thy ways; And if, as I believe, thy vein be good, The world will find thee after many days.”




W. Tibbles (1859-1928) Erythroxylon coca: a treatise on brain exhaustion, as the cause of disease, 1877, Helmsley: W. Allenby; Leeds: Joseph Dodgson; Leicester