Many pharmacological studies have focused and focus on the reparative and protective effects of PEA (Palmitoylethanolamide) on and in the nervous system. Only case studies though have been conducted on the effects of PEA in amyotrophic lateral sclerosis. The effect of PEA on the course of this divesting neurological disorder needs more attention.

Palmitoylethanolamide (PEA), a natural molecule that is present in living cells of most organisms, even plants, and can also be found in found, like in fish, seeds, and in eggs. The amounts, however, are small, and cannot be used for therapeutic purposes.

PEA is a fatty acid amide belonging to the group of saturated fatty acids. These fats are produced in the membrane of our cells, from palmitic acid, a very common precursor of fats. PEA is especially known for its anti-inflammatory and painkilling effects (1). Besides that, there have been several studies into the protective and reparative effects of PEA in the nervous system.

For instance, research in Alzheimer and Parkinson disease, indicating possible relevance and positive effects in patients (2-3). The protecting effect of PEA is attributed to the effects of certain receptors in the nucleus of the living cells, the peroxisome proliferator activated receptor-α (PPAR α). Activating this nuclear receptor leads to inhibition of inflammation reactions in the body is (2-3).

Studies have been conducted on the effect of PEA in the cell, or animal models for multiple sclerosis (MS), a disease resembling ALS in its inflammation of the nervous system.

On the internet one can find a number of descriptions of a patient with ALS that experience an improvement in bodily function after taking PEA (4). It seems quite worthwhile to continue studying the effects of PEA on ALS, as well as on MS.

Patients with ALS often want – with good reason – not to wait for further research and start using a possible effective substance already.

Often the thought ‘it doesn’t hurt to try’ comes into play. PEA clearly has no negative side effects, probably due to its structure as a simple fatty molecule.

Fat is an essential building block of the nervous system and a healthy amount of saturated and unsaturated fatty acids is important for it to function well. There is no proof for harmful effects of PEA as a dietary supplement in dosages up to 1800 mg daily.

PEA-opt® is a quality mark used exclusively for products that contain optimized palmitoylethanolamide (PEA). Optimized palmitoylethanolamide is natural PEA prepared by means of a modern patent for formulation. That’s why the PEA particles have a special quality, fineness and are finely distributed, enabling this product to optimally support the intake process in the body. This contributes to its effectiveness.