Friday, May 26, 2017

Palmitoylethanolamide works in the brain

The effect of palmitoylethanolamide (PEA), an endogenous fatty acid amide displaying neuroprotective actions, on glutamate release from rat cerebrocortical nerve terminals (synaptosomes) was investigated....

Use of palmitoylethanolamide in case of inflammations of the retina

Although the pathogenesis of diabetic retinopathy (DR) is still insufficiently understood, new evidences indicate 'retinal inflammation' as an important player in the pathogenesis of...

Palmitoylethanolamide against colon cancer

Mast cells and neuroimmune interactions regulate the severity of intestinal radiation mucositis, a dose-limiting toxicity during radiation therapy of abdominal malignancies. AIM: Because endocannabinoids (eCB) regulate...

Palmitoylethanolamide a natural painkiller: quite effective and safe!

A growing body of evidence suggests that neuroinflammation, which is characterized by infiltration of immune cells, activation of mast cells and glial cells, and...

Palmitoylethanolamide a natural painkiller for special headache

Nummular headache has been recently described as a primary disorder characterized by head pain exclusively felt in a small rounded area typically 2-6 cm...

Palmitoylethanolamide in neuropathic pain: effects of PEA on the brain

Background: Enhanced supraspinal glutamate levels following nerve injury are associated with pathophysiological mechanisms responsible for neuropathic pain. Chronic pain can interfere with specific brain areas...

Palmitoylethanolamide delayes morphine tolerance: a special characteristic of a natural painkiller

In spite of the potency and efficacy of morphine, its clinical application for chronic persistent pain is limited by the development of tolerance to...

Palmitoylethanolamide protects against myocardial infarction

Myocardial infarction is the leading cause of death, occurs after prolonged ischemia of the coronary arteries. Restore blood flow is the first intervention help...

Palmitoylethanolamide helps in infections to support the body in its defense

Background: Palmitoylethanolamide (PEA), an endogenous lipid and a congener of anandamide, possesses a wide range of effects related to metabolic and cellular homeostasis including anti-inflammatory...

Palmitoylethanolamide protects the visual fields in glaucoma

The purpose of this study is to assess the effect of palmitoylethanolamide (PEA) oral administration on intraocular pressure (IOP) and visual field damage progression...